After installing Ubuntu 9.10 I was unable to get Seesmic Desktop to keep passwords. Even after uninstalling AIR and Seesmic. Long story short, and a quick IM to Yama at Seesmic and he said I needed to simply delete the ELS folder from within AIR. Here’s the 1-2-3 of it all.
1. Close Seesmic Desktop.
2. Cut and paste this line (replacing user with your username) into terminal:
sudo rm -fdr /home/user/.appdata/Adobe/AIR/ELS
3. Restart Seesmic and tweet!
By the way: WOW! If only Yama worked for every company. 
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